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Defyne is the firmer of the two, and works best for deeper placements
Weber AE, Gallo MC, Bolia IK, Cleary EJ, Schroeder TE, Hatch GFR
Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks

While less common than flushing, these cardiovascular effects raise understandable concern
Treat it as non-negotiable as brushing your teeth
