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You can find more detail on B12 treatment timelines and schedules

Mild deficiency typically requires monthly injections
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Enteric bacterial enzymes may also destroy certain ingested agents, such as chlorpromazine

One is that erastin binds to mitochondrial VDAC2/3 in BJeLR cells and induces ferroptosis with aberrant ROS generated by the mitochondrial oxidative respiratory chain (Yang et al., 2020)
