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Elevated iron levels are also linked to oxidative stress and ferroptosis, a programmed cell death dependent on intracellular ferrous iron and impaired antioxidant defense systems (Abdukarimov et al., 2025)

doi: 10.1530/joe-17-0402 16 JamesJLLissamanANursalimYNSChamleyLW

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Promotes actin polymerization, cell migration, and structural protein expression, aiding softtissue repair, angiogenesis, and reduced fibrosis

These findings highlight the existence of a therapeutic window in which ferroptosis-targeting strategies may halt or even reverse the progression of IDD