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The combination is used in clinical practice under physician supervision based on mechanistic reasoning, preclinical evidence, and clinical experience

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[6] After deep intramuscular injection the lipophilic ester diffuses slowly from the oil depot, undergoes enzymatic cleavage to free testosterone and enters the systemic circulation, where roughly 98 % is reversibly bound to sex-hormone-binding globulin and albumin while the unbound fraction translocates across cell membranes to activate androgen receptors
