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doi: 10.1016/j.canep.2023.102342 163

In experimental models, suppression of spermatogenesis in the testes and degeneration of primordial follicles and granulosa cells in the ovaries are considered hallmark features of platinum-induced gonadotoxicity.8 Chemotherapeutic agents have been shown to deplete intracellular Glutathione (GSH), one of the major endogenous antioxidants, while simultaneously increasing Myeloperoxidase (MPO) activity, an indicator of inflammatory response, and elevating Malondialdehyde (MDA), a marker of lipid peroxidation.9 Co-administration of antioxidants during chemotherapy has therefore been proposed as a strategy to mitigate oxidative stress-induced tissue injury and improve therapeutic tolerance

The shot is the quick, focused option when B12 is your main concern, and it takes only a few minutes

Modifier rules for injection codes shift with every quarterly CMS update

Usually these trials have been found listed on the well known database of trials known as ClinicalTrials.Gov