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greater clinical integration requires clearer guideline recommendations and clinician awareness

[DOI] [PubMed] [Google Scholar] 150.Czapski G.A., Cakala M., Chalimoniuk M., Gajkowska B., Strosznajder J.B

This profound chemosensitization effect was achieved through the downregulation of drug transporters (MDR1, BCRP, MRP2, and MRP7), the reduction of 5FU efflux, and the modulation of the FOXO3-FOXM1 axis

Strategies intervening in this metabolic switch, inhibiting glycolysis and glutaminolysis, and promoting OXPHOSkeeping mitochondria healthycould be interesting strategies in the fight against these conditions and others related to the Warburg effect (Manzi et al., 2015

GBA-related PD (GBA-PD) is associated with faster motor and cognitive decline, especially affecting visuospatial and executive functions (De Michele et al., 2023), the rs12411216 variant of GBA being associated with PD-MCI (Jiang et al., 2020)