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These soaps help synthesize collagen production and stimulate the growth of new skin cells

however, the involvement of CYP3A5 in acetaminophen oxidation has not been reported and if occurs, it might be due to a big overlap in substrate selectivity between CYP3A enzymes

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Rare but serious risks include pulmonary hypertension, valvular heart disease, significantly high blood pressure, arrhythmias, and psychosis in predisposed individuals

Death is reported in about 10% of larger historic series
