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These tests not only measure B12 levels but also help identify potential underlying causes of deficiency

If glucose is available in excess, aldose reductase convert glucose into sorbitol through the polyol pathway [188]

72 Vitamin B 12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including Alzheimers disease and vascular dementia protection)

However, data on PA concentrations in the brain remain limited

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