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Certain histological characteristics of IC, such as the thinning of the bladder epithelium, erosion, and heightened mast cell infiltration, suggest that the condition may result from a deficiency in the regenerative capacity of bladder epithelial cells, along with immune system dysfunction (Slobodov et al., 2004)

Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV

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Another possibility is the use of dupilumab (IL-4/IL-13 receptor blocker), which has shown promising results in the treatment of various eosinophil-associated diseases including atopic dermatitis, asthma, nasal polyps, and eosinophilic esophagitis (232, 233)