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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Fullerton M., McFarland R., Taylor R.W., Alston C.L

It causes a selective loss of upper motor neurons (UMN) of the motor cortex and lower motor neurons (LMN) of the brainstem and spinal cord (Brown and Al-Chalabi, 2017

However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

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