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TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]

Such conditions include obesity and type 2 diabetes mellitus.] Figure 18.17 Metabolism of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL)

Bulksupplements suggest that using L-Carnitine may boost energy levels, improve exercise performance, support brain and heart function, and aid in exercise recovery

Further mechanistic investigations are warranted to clarify the exact mechanisms mediating the synergistic effect of L-carnitine and synbiotic combined therapy on weight and metabolic parameters