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When ALD advances to cirrhosis, liver failure, or hepatocellular carcinoma, where the liver loses normal function and conventional treatments are ineffective, liver transplantation becomes the most effective method to increase survival rates by providing a normally functioning liver

World journal of gastroenterology: WJG 13 , 49674973 (2007)

The authors stratified their results based on the severity of hepatic encephalopathy at the time of inclusion and demonstrated that NAC-treated patients with mild hepatic encephalopathy (grade I and II) had better survival compared to controls

Once Nrf2 translocates to the nucleus, it forms heterodimers with small Maf (MafG, MafK and MafF) and Jun (c-Jun, Jun-D, and Jun-B) proteins to bind to ARE [108]

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