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DMG levels in the COC user group were positively correlated with methoxyestrogens but negatively correlated with hydroxyestrogens, which may indicate that the methylation of estrogens is dependent on the methylation capacity provided by the betaine-DMG conversion

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An NNMT inhibitor like 5-amino-1MQ could help by stimulating the synthesis of NAD+, a vital cofactor in the electron transport chain