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According to the US Food and Drug Administration (FDA), more than 90% of neuroprotective drugs tested at the clinical level to treat central nervous system (CNS) diseases have not been approved due to their poor bioavailability [27]
Others rely on published literature and USP default BUD assignments
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[DOI] [PubMed] [Google Scholar] 36.Clark M.A., Hentzen B.T., Plank L.D., Hill G.I
