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Moreover, the same study found that patients with severe enteritis showed high abundance of Shigella and Lachnospiraceae Clostridium

Still, all these glutamatergic related factors account for a very small proportion of the overall heritability in schizophrenia and do not support a major role for genes known to impair NMDA-R function

Steroids 150:108434

In vitro studies have demonstrated that IL-10 opposes the cellular functions induced by TNF- and IFN-.50 IL-10 knockout mice, which are widely used as a model of spontaneous colitis, show increased intestinal permeability with elevated TNF-, IL-1, and IL-6 expression prior to exhibiting histologic signs of intestinal inflammation.51 These observations suggest that IL-10 has a role in the protection of the intestinal barrier

Okano T, Ohnuma T, Holland JF, Koeffler HP, Jui H