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The Phase 3 clinical trial of SURPASS-AP-Combo is Tirzepatide's first study conducted mainly in Chinese patients with type 2 diabetes, led by Professor Ji Linong of Peking University People's Hospital

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This glutamate elevation in synaptic strength results in heightened neuronal synchrony, leading to increased amplitude of brain electrical activity oscillations, potentially contributing to the generation of epilepticlike discharges in patients with GC1 deficiency

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