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Therefore, the oxidation of protein sulfhydryl groups is a typical indicator of oxidative damage at the protein level in human RBCs

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Trends Biochem 2013

Although randomized studies have not shown an overall effect on the frequency of exacerbations, a post-hoc analysis of a clinical trial reported a decrease in their severity (87) Overall, these results demonstrate that A1PI augmentation therapy offers significant benefits in slowing the progression of emphysema and improving clinical outcomes for patients with AATD, underscoring the importance of timely and continuous treatment

doi:10.1016/j.tibtech.2005.08.002