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Why is AOD-9604 supplied as a lyophilized powder rather than a pre-mixed solution

Ruperto N, Murray KJ, Gerloni V, Wulffraat N, De Oliveira SKF, Falcini F, Dolezalova P, Alessio M, Burgos-Vargas R, Corona F, Vesely R, Foster H, Davidson J, Zulian F, Asplin L, Baildam E, Consuegra JG, Ozdogan H, Saurenmann R, Joos R, Pistorio A, Woo P, Martini A (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate

Physiologically, CDKN2A encodes two proteins p16 Ink4a and p14 Arf through distinct translational programs

(2) enhancing their distribution in target tissues
