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Description
The immune response is localized to the proximal small intestine and causes the characteristic histologic findings of villous atrophy, crypt hyperplasia, and intraepithelial lymphocytosis

Starting conservatively and adjusting based on individual response remains the best approach to minimize any negative effects while maximizing benefits

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At present, there is no definitive evidence of the interaction between the circadian clock system and the GH/IGF-1 axis and the pathophysiological mechanism causing metabolic disorders
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