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In a Phase II readout released in August 2022, the pharma touted a 15.6% drop in body weight in patients taking CagriSema, versus 5.1% in comparators on semaglutide alone and 8.1% in patients treated with only cagrilintide

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Further in vivo testing is required (Zharkova et al

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A brief discussion of these enzymes is included here because even though mercapturates are usually detoxification end products, the mercapturate itself can sometimes be toxic, for example, in the case of mercapturates derived from halogenated alkenes (Boogard et al., 1989, Commandeur et al., 1991, Newman et al., 2007)