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At baseline, the average age of the patients was 38.94 14.55, the average BHB level was 0.16 0.08 mmol/L (negative, as expected prior to starting MAD), the average fasting triglyceride level was 102.95 76.03, average body weight was 80.5 23.18 kg, and average number of seizures per week was 2.68 3.15

45-56, DOI: 10.1016/j.cmet.2007.10.013

Significantly, melatonin supplementation has demonstrated the capacity to alleviate oxidative stress and impede the accumulation of A, as well as tau hyperphosphorylation, in the hippocampus of aged rats exhibiting brain insulin resistance induced by a high-fat diet [135]