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Typhi: an in silico approach

Copyright National Institutes of Health (NIH), 2025 Introduction G protein-coupled receptors (GPCRs) are cell surface receptors that receive and transmit signals from outside the cell, regulating a broad range of human physiological processes, making them a major target of pharmacological allosteric modulators

Hirvonen HE, Mikkelsson MK, Kautiainen H, Pohjolainen TH, Leirisalo-Repo M

For a volume of 71,580 patients, the mean number of intramuscular injections per patient was 6.15 per year

Spacing them by several hours eliminates this minor concern
