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Class B Findings Absent posterior tibial pulse, absent dorsalis pedis pulse, or advanced trophic changes (three of: decrease or absence of hair growth, nail thickening, pigmentary changes, thin shiny skin texture, rubor or redness)

Neurotoxicity is apparently dose-dependent (frequent for 250350 mg/m 2 , almost certain if dosage exceeds 500600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]

Kerksick C, Willoughby D

3.2.1 Bifidobacterium breve As a key commensal representative, B

Support for skin repair: Some antioxidants stimulate collagen and elastin production, promoting the regeneration and repair of damaged skin