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This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)

Tofthagen CS, Cheville AL, Loprinzi CL.The physical consequences of chemotherapy-induced peripheral neuropathy

Longhi and Uversky, 2010

Recovery from the degenerative phenotypes and reduced oxidative stress therefore, contributed to better survivability of the Sp- park 13 flies, which was comparable to Oregon R + (Fig

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