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Melanotan II is a non-selective MC1RMC5R agonist
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A study on mCRP showed that it induced proinflammatory cytokine release, including IL-6/8, MMP13, and NOS2 in both human and murine chondrocytes, thereby proposing a possible mechanism of boosted cartilage catabolism in osteoarthritis [104]
10.1152/jappl.1996.80.6.2250 30
