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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides 75 , 95

doi: 10.1016/S0304-3940(98)00242-0 27

[] The limitations of this study include the lack of precise consideration of the protein and calorie needs of patients, the inability to assess long-term effects, inappropriate initiation timing of parenteral nutrition, and failure to account for presupplementation glutamine levels

Recommended dietary intakes and allowances around the world- an introduction

Kuban K, et al