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Description
5-Amino-1MQ is an oral NNMT (nicotinamide N-methyltransferase) inhibitor that works by blocking an enzyme that depletes cellular NAD+ and SAM
Small errors can lead to denials or reduced reimbursement
Pyo et al., Arch Pharm Res, 2007)
Some patients get paradoxical fatigue or headaches from B12 due to detoxification effects, in which case lower your dose
Furthermore, in MM, a subpopulation of regulatory T cells (Tregs) shows increased CD38 expression compared to T constitutive cells (Tcons), which enhances their immunosuppressive effect
