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60 years of metformin use: a glance at the past and a look to the future

The choice between medications should rest primarily on efficacy data, tolerability, availability, and cost rather than the B12 inclusion, which is valuable in both formulations

Female rats weighing 170230 g and aged 1214 weeks were housed under controlled environmental conditions (22C 2C temperature, 12-hour light-dark cycle) in the animal facility at the College of Education Pure Sciences, Thi-Qar University
