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Subsequent work by Heffernan and coworkers (2001) confirmed the peptides effects in obese mouse models, with chronic administration associated with reduced body weight gain and decreased adiposity without concurrent changes in food intake

Under conditions of oxidative stress, ROS initiate the chain reaction of lipid peroxidation, culminating in the generation of toxic lipid hydroperoxides that compromise membrane integrity and cellular viability (Su, 2019)

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