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Addressing this issue by establishing unified experimental frameworks will be instrumental in accelerating progress and ensuring the clinical relevance of future discoveries

10.3390/plants10050832 39 GBD (2021)

This response may be similar to that observed in toxic milk mice [26, 28] or could result from CuCl-induced toxicity, as cell viability dropped to 60% at 0.6mmol/l

With increasing severity of NASH and fibrosis, BA levels tend to increase and the composition of BAs changes, which may partly result from insulin resistance,89 impaired hepatobiliary excretory function1820 and altered microbial BA metabolism caused by NASH-associated dysbiosis.55 Despite increased BA levels, FXR and FGF19 signalling is impaired, resulting in increased BA synthesis90 91 and BA toxicity could contribute to the hepatocellular injury and even carcinogenesis in NASH.4 12 92 Thus, restoration of FXR signalling and BA and lipid homoeostasis may explain at least part of the therapeutic effects of FXR ligands in NAFLD/NASH

Finally, the synthesized data were analyzed to provide a comprehensive understanding of the molecular mechanisms through which quercetin may treat acne, while discussing the limitations of existing research and potential future research directions