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Concurrently, mitochondrial dysfunction (via Acyl-CoA Synthetase 4 (ACSL4) upregulation, PB1-F2/M2/NS1-mediated disruption, and Dihydroorotate Dehydrogenase (DHODH) inhibition) (99), peroxisome (PX) degradation (pexophagy), and Indoleamine 2,3-Dioxygenase 1 (IDO1)Inducible Nitric Oxide Synthase (iNOS)mediated ONOO - production collectively intensify lipid peroxidation (100)

Indeed, SNPs of PDCD11 gene, coding the NF- B-binding protein (NFBP) or the protein RRP5 homolog, have shown a statistically significant association with schizophrenia according to the GWAS results [91]

We have identified a group of receptor kinases, POLARLY LOCALIZED KINASEs (PLKs), that polarize to different plasma membrane domains in root cells and function in development

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doi: 10.1016/j.pharmthera.2019.05.004 217 WangH.LiuB.ChenH.XuP.XueH.YuanJ