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Available data do not indicate mutagenic, teratogenic, or carcinogenic effects in the models tested

Safarinejad MR, Shafiei N, Safarinejad S (2010) The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

Importantly, the 9-me-BC-treated rats were otherwise healthy, meaning that the results of the study can be extrapolated to potential nootropic efficacy in healthy humans, rather than, as is often the case, surmising potential effects based off of studies normally performed in either animal models of cognitive disorder, or in humans with reduced mental function

Such individuals should not eschew B12 supplementation and thus trade a fair certainty of benefit to prevent a vague and not firmly established risk of harm

Part of the mechanism relates to decreased cofactor availability (such as B vitamins)