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In depression, abnormal iron deposition in the prefrontal cortex and hippocampus triggers the accumulation of lipid peroxides through the Fenton reaction, directly damaging synaptic plasticity-related proteins (such as BDNF/TrkB signaling pathway), resulting in atypical neural network connections, a phenomenon closely linked to cognitive deterioration and emotional disturbances in patients (Liu et al., 2024)

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