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Free Radic Biol Med 65: 114, 2013

This genomic influence positions GHK-Cu as one of the most powerful naturally-occurring gene modulators identified by modern science

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General Chemicals Used for This Study Glutathione, Glutathione disulfide (GSSG), antibiotics (ciprofloxacin, amikacin, Augmentin, gentamicin and tobramycin), resazurin dye, crystal violet solution, Phosphate buffered saline (1 PBS) and Hydrogen peroxide (H 2 O 2 ) were all obtained from Sigma-Aldrich (Sydney, Australia)

Yet genetics highlight PIF4s privileged rolewithin the PIF quartet (PIF1, PIF3, PIF4, and PIF5), only loss of PIF4 markedly dampens thermosensory hypocotyl elongation, whereas single knockouts of the others have minimal effect 7,93