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Nature 2018, 561 (7721), 6369
SN Education
(5) OE group: Cells transfected with an overexpression vector for gene GCLC
A seminal study published in Science demonstrated that plasma from exercised aged mice transfers enhanced adult hippocampal neurogenesis and cognition to sedentary aged recipients, identifying the liver enzyme GPLD1 as a key mediator whose systemic elevation recapitulates these benefits without entering the brain [32]
