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Excessive alcohol and drug use diminishes the amount of NAD naturally found in the body

injections of 100 nmol kg 1 MK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1 ( n = 6 mice and n = 3 cages), 100 nmol kg 1 , GLP-1MK-801 ( n = 6 mice and n = 3 cages), co-administration of 100 nmol kg 1 GLP-1 and 100 nmol kg 1 MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 14 days