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No single compound modulates all of these processes simultaneously

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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

The blink reflex was performed by blowing air into the eye at a distance of 2 cm away from the eye by the use of a 5 ml syringe without a needle, and the movement and closure condition of the eyelid were observed