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doi: 10.1016/bs.mie.2021.11.023

TB-500s biological activity is mediated primarily through binding of the LKKTETQ actin-binding motif to G-actin and sequestering actin monomers, regulating actin polymerisation dynamics, and activating downstream signalling through the PI3K/Akt pathway that promotes cell survival, migration, and proliferation in multiple cell types relevant to tissue repair including endothelial cells, fibroblasts, keratinocytes, and myocytes

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