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In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18,20,50,87], although CNS depression may be delayed if a slow-release preparation has been ingested [12,50]

Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro

Studies have shown that GLUT2, which has a relatively low affinity for glucose, is specifically upregulated in liver cancer and colorectal cancer, consistent with the metabolic characteristics of their tissues of origin [30, 31]

PNSDs, peripheral nervous system diseases

168 A clinical trial in which 128 subjects received 400 mg valerian extract, a commercial valerian product (not otherwise described), and placebo in random order and on three non-consecutive nights found the valerian extract increased subjective sleep quality and shortened the time to fall asleep