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-hydroxybutyrate becomes a metabolic decoy that feeds normal tissues and lymphocytes while starving the tumor 383 , an idea first articulated by Sidney Weinhouse, the opponent of the metabolic theory of cancer 300,301 , and elaborated in modern ketogenic-diet studies 25

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Therefore, such chemo-PDT treatment with H-MnO 2 -PEG/C&D in combination with PD-L1 blockade could not only effectively kill primary tumor cells with direct light exposure, but also inhibit the growth of distant tumors (e.g., tumors located deeply inside the body, or too small to be detected before treatment) spared from light exposure

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Ren F., Aliper A., Chen J., et al., A SmallMolecule TNIK Inhibitor Targets Fibrosis in Preclinical and Clinical Models, Nature Biotechnology 43 (2025): 6375