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and third, helplessness when confronted with painful circumstances ( Consequently, when viewed in terms of our findings, we hypothesize that the elevated levels of neurometabolites may reflect an increase in insula activity and interoceptive awareness, which, in turn, causes patients to focus more on their pain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Ng T.K., Chu K.O., Wang C.C., Pang C.P

Gene set enrichment analysis highlighted the early activation of oxidative stress-related pathways, including oxidative phosphorylation and ROS generation, as early as 1-h post-APAP exposure

Hothorn T, Hornik K, van de Wiel MA, Zeileis A