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The regulation of mitochondrial mass and function is governed by two conserved processes, mitobiogenesis and mitophagy

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Finally, the protonated glutamate residue donates a hydrogen to the amine of the -linked peptide, releasing an amino acid with a free amino group (Figure 3) ( FIGURE 3 The ChaC-like family proteins, including CHAC1, preferentially degrade reduced glutathione but can also break down other -glutamyl amino acids ( Although CHAC2 enzymes in Leishmania major were shown to degrade only reduced and not oxidized glutathione, this specificity has yet to be confirmed for CHAC1 ( CHAC2 is both evolutionarily older and structurally distinct from CHAC1

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For example, they have been shown to significantly inhibit phosphoinositol 3-kinase (PI3K) and phosphorylated Ak strain transforming (Akt) levels in the airways, as well as reduce excess oversecreted mucin 5AC (Muc5ac) during the development of asthma