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Furthermore, recent clinical trials, despite great variability in efficacy outcomes, have consistently confirmed the favorable safety profile of NAC across a wide range of therapeutic areas

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There are indications that silymarin may have a mild oestrogen-like effect

Methods Selection of studies for review The inclusion criteria for studies were defined as: (a) participants diagnosed with an autism spectrum disorder using standardised criteria such as the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV-R [51] or the Childhood Autism Rating Scale (CARS) scores [52]