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Supporting this, it was shown that downregulation of GHSR-1a in the small intestine delays transit in vagotomised mice [125]

Composed of 15 amino acids (Gly-Glu-Ser-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu), it is renowned for its exceptional molecular stability, particularly its resistance to enzymatic degradation in various physiological environments

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Typical effective doses range from 140-800mg of silymarin daily, standardized to 70-80% silymarin content

The area under the GH curve was significantly lower in older subjects, whereas the elimination half-life was similar in the two groups, suggesting both an increased metabolic clearance rate and apparent distribution volume of GH in older subjects