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Upon activation by toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), macrophages initiate the synthesis of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other inflammatory biomarkers, resulting in further hepatic injury (Guilliams and Scott 2022)

When we look at the link between the skin as mentioned earlier conditions they all have been shown to correlate leaky gut, an imbalance in intestinal flora, lack of protein absorption, inflammation, celiacs disease and other autoimmune disorders

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