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doi: 10.1056/NEJMoa0907441

Nrf2, a nuclear transcription factor, translocates to the cell nucleus to upregulate HO-1, converting heme to biliverdin, iron, and CO [108]

Survival mechanisms take precedence, while non-essential functions, such as reproduction and sexual desire, are rapidly downregulated

Children with ASD were treated with one of these three treatments or placebo and the effect of each treatment over an equivalent 12 week period was compared to the effect of placebo over the same time period

By day 52, cumulative Dox exposure reached 30 mg/kg, at which point significant LV dilation and functional failure are known to occur, consistent with prior models [1]