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qRTPCR and immunofluorescence confirmed reduced NFE2L2 RNA and protein expression in psoriatic lesions compared to normal skin (Fig

TGF- has been shown to downregulate activity of Glutamine Cysteine ligase, a rate-limiting step enzyme involved in the synthesis of GSH [75]

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some tumors rely on it for survival under high oxidative pressure, while deficiencies in healthy cells might promote tumor initiation through DNA damage
