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Description
In hyperglycemia, there is enhanced metabolism of glucose through the polyol (sorbitol) pathway, which also results in enhanced production of Enzymatic sources of augmented generation of ROS in diabetes include nitric oxide synthase (NOS), NAD(P)H oxidase, and xanthine oxidase (Guzik et al., 2+ -calmodulin
[DOI] [PubMed] [Google Scholar] 97.Li J., Liang Y., Mao H., Deng W., Zhang J
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-1-dependent mechanism
O.TroupD
All primary findings are preclinical
