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Larger PEGs (up to 40 kDa) may be used in PEGylated biopharmaceuticals, and safety testing for these formulations are done during development on a case-by-case basis [86]

doi: 10.1016/j.jacc.2020.08.045 7 SwiatkiewiczIPatelNTVillarreal-GonzalezMTaubPR

Antioxidants reduce the local concentration of molecular oxygen, remove pro-oxidative metal ions, capture aggressive ROS (superoxide anion radicals and hydrogen peroxide, etc.), remove chain-starting free radicals (hydroxyl, peroxyl, alkoxyl, etc.), inhibit the sequential production of radical chains, and quench singlet oxygen [94, 95]

Pt and its prodrugs could be conjugated on the surface of inorganic NPs, for instance, via the chemical reaction between specific functional groups (e.g., NH 2 and COOH) (Yang et al., 2019)

Cangma Huadu granules attenuate H1N1 virus-induced severe lung injury correlated with repressed apoptosis and altered gut microbiome