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Microglia, astrocytes, oligodendroglia, neurons and infiltrating innate and adaptive immune cells, cytokines, immunoglobulin and complement may contribute to inherently negative and maladaptive destructive processes

It is multifactorial

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Xu J.-J., Zhang X.-F., Jiang Y., Fan H., Li J.-X., Li C.-Y., Zhao Q., Yang L., Hu Y.-H., Martin C., et al

The efficacy of a product depends on factors like concentration, stability, and skin penetration

EGCG enhances mitochondrial function, reduces oxidative stress, modulates protein aggregation, and regulates inflammation [80]
